Cardiac Amyloidosis: The Importance of Surveillance in a Patient With an Initial Negative Cardiac Biopsy

Rajiv Ananthakrishna; Rachael Lloyd; Bryone J Kuss; Joseph B Selvanayagam

doi:10.1016/j.jaccas.2019.11.041

Cardiac Amyloidosis: The Importance of Surveillance in a Patient With an Initial Negative Cardiac Biopsy

JACC Case Rep. 2020 Jan 29;2(2):282-285. doi: 10.1016/j.jaccas.2019.11.041. eCollection 2020 Feb.

Authors

Rajiv Ananthakrishna¹, Rachael Lloyd¹, Bryone J Kuss², Joseph B Selvanayagam¹

Affiliations

¹ Department of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
² Department of Molecular Medicine (Haematology and Molecular Genetics), Flinders University, Adelaide, Australia.

Abstract

Cardiac amyloidosis is a progressive disorder and is sometimes difficult to diagnose even when suspected in the appropriate clinical setting. We present an interesting case of rapidly progressive light-chain cardiac amyloidosis and highlights the importance of close monitoring even when the initial biopsy and imaging findings are not pathognomonic for amyloidosis. (Level of Difficulty: Beginner.).

Keywords: AL, light-chain; ATTR, transthyretin; CA, cardiac amyloidosis; CMR, cardiac magnetic resonance; ECV, extracellular volume; MGUS, monoclonal gammopathy of unknown significance; NT-proBNP, N-terminal pro-B-type natriuretic peptide; amyloidosis; biopsy; cardiac magnetic resonance.

Publication types

Case Reports