Clinical Manifestations of Hospitalized COVID-19 Patients in Bangladesh: A 14-day Observational Study

Modhusudon Shaha; Md A Islam; Faizul Huq; Bithi Roy; Md A Kabir; Md Salimullah; Mamun Al Mahtab; Sheikh Mf Akbar

doi:10.5005/jp-journals-10018-1340

Clinical Manifestations of Hospitalized COVID-19 Patients in Bangladesh: A 14-day Observational Study

Euroasian J Hepatogastroenterol. 2021 Jan-Jun;11(1):14-20. doi: 10.5005/jp-journals-10018-1340.

Authors

Modhusudon Shaha^{1

2}, Md A Islam³, Faizul Huq⁴, Bithi Roy⁵, Md A Kabir¹, Md Salimullah², Mamun Al Mahtab⁶, Sheikh Mf Akbar⁷

Affiliations

¹ Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
² National Institute of Biotechnology, Dhaka, Bangladesh.
³ Directorate General of Medical Services, Bangladesh Army Medical Corps, Dhaka, Bangladesh.
⁴ Department of Medicine, Combined Military Hospital, Dhaka, Bangladesh.
⁵ Department of Agronomy, Bangladesh Agricultural University, Mymensingh, Bangladesh.
⁶ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh.
⁷ Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

Abstract

Objectives: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently a significant public health concern and causing a pandemic in the world. Despite immense attention to the coronavirus disease 2019 (COVID-19), very little attention has been given to the kinetics of disease progression in infected patients. Therefore, in this study, we present a 14-day clinical observation of hospital-admitted COVID-19 patients.

Methods: After recording the demography of 42 COVID-19 patients on day 1, we observed the clinical progression for 14 days by investigating the hematological and biochemical responses of patients' blood and serum, respectively.

Results: Approximately, 62% of the hospital-admitted COVID-19 patients presented cough, followed by fever (∼52%). The top comorbidities of these patients were hypertension (30%) and diabetes mellitus (19%). The average blood hemoglobin (Hb) level was slightly low among the patients in the early days of infection and went up to the normal level on the later days. A substantial increase in the level of ALT or SGPT [up to 106 IU/L; standard error of the mean (SEM): 12.64] and AST or SGOT (up to 64.35 IU/L; SEM: 5.013) in COVID-19 patients was observed, which may suggest that infection with coronavirus is associated with the functionality of other organs of COVID-19 patients.

Conclusion: This 14-day observational study may help clinicians to decide the choice of treatment for COVID-19 patients.

How to cite this article: Shaha M, Islam MA, Huq F, et al. Clinical Manifestations of Hospitalized COVID-19 Patients in Bangladesh: A 14-day Observational Study. Euroasian J Hepato-Gastroenterol 2021;11(1):14-20.

Keywords: Blood hemoglobin; COVID-19; Clinical manifestations; Comorbidity; Liver functionality; Pneumonia.