Establishment of a non-squamous cell carcinoma of the larynx nomogram prognostic model and prognosis analysis

Lin Fan; Rui Zhao; Xiumei Chen; Yaohui Liu; Linli Tian; Ming Liu

doi:10.1016/j.anl.2021.07.008

Establishment of a non-squamous cell carcinoma of the larynx nomogram prognostic model and prognosis analysis

Auris Nasus Larynx. 2022 Apr;49(2):240-247. doi: 10.1016/j.anl.2021.07.008. Epub 2021 Jul 25.

Authors

Lin Fan¹, Rui Zhao¹, Xiumei Chen², Yaohui Liu¹, Linli Tian³, Ming Liu⁴

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University, Haerbin,China.
² Department of Otolaryngology-Head and Neck Surgery,Yantai Yuhuangding Hospital,Yantai,China.
³ Department of Otolaryngology-Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University, Haerbin,China. Electronic address: tianlinli78@163.com.
⁴ Department of Otolaryngology-Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University, Haerbin,China. Electronic address: liumingorl@qq.com.

PMID: 34315609
DOI: 10.1016/j.anl.2021.07.008

Abstract

Objective: We aimed to compare the prognosis of laryngeal squamous cell carcinoma (LSCC) and nSCCs of the larynx.Then we established a nomogram for nSCCs of the larynx.

Methods: Prognosis between the 529 pairs nSCCs of the larynx patients and LSCC patients were compared after propensity score matching (PSM). 591 nSCCs of the larynx patients were divided into the modeling and validation groups. Univariate and multivariate Cox analyses obtain independent prognostic factors, which were then included in the nomogram to predict the 3 and 5 year survival. Prognostic accuracy of the nomogram was evaluated using the consistency index (C-index) and the calibration curve.

Results: Prognosis of nSCCs of the larynx was poorer than LSCC. Age, race, tumor location, tumor-node-metastasis stage, and method were independent prognostic factors of nSCCs of the larynx (P < 0.05). Internal and external validation proves the nomogram reliable CONCLUSION: The nomogram showed good prognostic accuracy and would assist clinicians in making more accurate evaluations for patients.

Keywords: Laryngeal cancer; Nomogram; PSM analysis; Prognosis.

MeSH terms

Head and Neck Neoplasms*
Humans
Laryngeal Neoplasms* / pathology
Larynx*
Nomograms
Prognosis