PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke

Stroke. 2021 Aug;52(9):e545-e547. doi: 10.1161/STROKEAHA.121.035677. Epub 2021 Jul 28.

Abstract

[Figure: see text].

Keywords: cholesterol; glucose; ischemic stroke; lipoproteins; prognosis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism
  • Brain Ischemia / genetics
  • Brain Ischemia / metabolism*
  • Hemorrhage / genetics*
  • Ischemic Stroke / genetics
  • Ischemic Stroke / metabolism*
  • Mice
  • Mice, Obese
  • Proprotein Convertase 9 / genetics*
  • Proprotein Convertase 9 / metabolism*
  • Risk Factors
  • Stroke / genetics
  • Stroke / metabolism

Substances

  • Pcsk9 protein, mouse
  • Proprotein Convertase 9