Particle-bound PAHs induced glucose metabolism disorders through HIF-1 pathway

Siqi Wu; Zhongli Chen; Li Yang; Yulin Zhang; Xiaohe Luo; Jinsong Guo; Ying Shao

doi:10.1016/j.scitotenv.2021.149132

Particle-bound PAHs induced glucose metabolism disorders through HIF-1 pathway

Sci Total Environ. 2021 Nov 25:797:149132. doi: 10.1016/j.scitotenv.2021.149132. Epub 2021 Jul 20.

Authors

Siqi Wu¹, Zhongli Chen¹, Li Yang¹, Yulin Zhang², Xiaohe Luo³, Jinsong Guo¹, Ying Shao⁴

Affiliations

¹ Key Laboratory of the Three Gorges Reservoir Eco-environment, Ministry of Education, Chongqing University, 174 Shazheng Road Shapingba, 400045 Chongqing, China.
² Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba disctrict, 400030 Chongqing, China; Chongqing Cancer Institute, 181 Hanyu Road, Shapingba disctrict, 400030 Chongqing, China; Chongqing Cancer Hospital, 181 Hanyu Road, Shapingba disctrict, 400030 Chongqing, China.
³ The Center of Clinical Research of Endocrinology and Metabolic Diseases in Chongqing, 404000 Chongqing, China; Department of Laboratory Medicine, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, 404000 Chongqing, China.
⁴ Key Laboratory of the Three Gorges Reservoir Eco-environment, Ministry of Education, Chongqing University, 174 Shazheng Road Shapingba, 400045 Chongqing, China. Electronic address: ying.shao@cqu.edu.cn.

PMID: 34311363
DOI: 10.1016/j.scitotenv.2021.149132

Abstract

Vehicle exhaust, as one of the most important compositions of air pollution, induced various adverse health effects, especially diabetes, on human beings. Even though monitoring and epidemiological data indicates that particle-bound polycyclic aromatic hydrocarbons (PAHs) is an inducing factor of diabetes, the specific causative mechanisms are still unclear. In the current study, the concentration of particulate matters (PMs, including PM_1.0, PM_2.5 and PM_10.0) and PAHs was investigated at rush hour of weekday in three urban underground parking garages (UPGs). To evaluate the impacts of particle-bound PAHs on human beings, analysis of non-target metabolomics and unmetabolized PAHs were conducted for UPG and non-UPG worker urine samples. The results showed that the highest concentrations of PMs and total PAHs were found at the UPG entrance. The concentrations of unmetabolized 5-6 rings PAHs in the UPG worker urine were significantly higher than that in non-UPG worker urine samples, which induced glucose metabolism disorders through hypoxia-inducible factor 1 (HIF-1) signaling pathway. This could be a reason for particle-bound PAHs induced-diabetes on road workers, drivers and garage staff. These findings can serve as a step towards air pollution management and the pathological mechanism analysis of environmental factor induced-diseases.

Keywords: Hypoxia-inducible factor 1 signaling pathway; Public health; Unmetabolized 5-6 rings PAHs; Vehicle exhaust.

MeSH terms

Air Pollutants* / analysis
Air Pollutants* / toxicity
Environmental Monitoring
Glucose Metabolism Disorders*
Humans
Particulate Matter / analysis
Particulate Matter / toxicity
Polycyclic Aromatic Hydrocarbons* / analysis
Polycyclic Aromatic Hydrocarbons* / toxicity
Seasons

Substances

Air Pollutants
Particulate Matter
Polycyclic Aromatic Hydrocarbons