Avermectin (AVM) is a biopesticide with low toxicity and high activity, but has limited use due to its poor water solubility and easy decomposition. A delivery system that can stabilize this biopesticide can play a significant role for improving its biological activity. Herein, water-dispersible functionalized polysuccinimide nanoparticles (PAD) were prepared by a ring-opening reaction and subsequently used to encapsulate AVM via self-assembly to form AVM@PAD nanoparticles with a loading ratio of 10.04 %. The half-life under UV radiation (300 W) of AVM@PAD was three times higher than that of free AVM, demonstrating the excellent protective ability of PAD. In addition, AVM@PAD nanoparticles could sustain the release of AVM for 70 h with a cumulative release rate of 70 %. AVM@PAD nanoparticles also showed a pH-responsive release, and their maximum cumulative release rate was at neutral pH. Moreover, the median lethal concentration (LC50) value of AVM@PAD with respect to Plutella xylostella was 34.50 mg/L, while that of free AVM was 56.05 mg/L. These results showed that the AVM@PAD nanoparticles can potentially and effectively promote drug stability and biological activity in agriculture.
Keywords: Avermectin; Polysuccinimide; Water-based nanocarriers; p-amino salicylic acid; pH-responsive release.
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