QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain

Pediatr Infect Dis J. 2021 Sep 1;40(9):e348-e351. doi: 10.1097/INF.0000000000003173.

Abstract

In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Humans
  • Interferon-gamma / analysis
  • Interferon-gamma Release Tests / instrumentation
  • Interferon-gamma Release Tests / standards*
  • Male
  • Predictive Value of Tests
  • Prospective Studies
  • Reagent Kits, Diagnostic / standards*
  • Sensitivity and Specificity
  • Spain
  • Tuberculosis / diagnosis*

Substances

  • Reagent Kits, Diagnostic
  • Interferon-gamma