The loopy world of cohesin

Kazuhiro Maeshima; Shiori Iida

doi:10.7554/eLife.71585

The loopy world of cohesin

Elife. 2021 Jul 26:10:e71585. doi: 10.7554/eLife.71585.

Authors

Kazuhiro Maeshima^{1

2}, Shiori Iida^{1

2}

Affiliations

¹ Genome Dynamics Laboratory, National Institute of Genetics, Mishima, Japan.
² Department of Genetics, School of Life Sciences, Sokendai (Graduate University for Advanced Studies), Mishima, Japan.

Abstract

DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.

Keywords: DNA loop extrusion; S. cerevisiae; S. pombe; biophysical simulation; chromosomes; cohesin; computational biology; gene expression; human; sister chromatid cohesion; smc complexes; structural biology; systems biology.

Publication types

Comment

MeSH terms

Cell Cycle Proteins* / genetics
Chromosomal Proteins, Non-Histone* / genetics
Chromosomes
Cohesins
DNA

Substances

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA