Expression and Clinical Significance of Lactate Dehydrogenase A in Colon Adenocarcinoma

Yutong Wang; Hui Nie; Zhiming Liao; Xiaoyun He; Zhijie Xu; Jianhua Zhou; Chunlin Ou

doi:10.3389/fonc.2021.700795

Expression and Clinical Significance of Lactate Dehydrogenase A in Colon Adenocarcinoma

Front Oncol. 2021 Jul 9:11:700795. doi: 10.3389/fonc.2021.700795. eCollection 2021.

Authors

Yutong Wang¹, Hui Nie¹, Zhiming Liao¹, Xiaoyun He¹, Zhijie Xu¹, Jianhua Zhou^{1

2

3}, Chunlin Ou^{1

2

3}

Affiliations

¹ Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
³ Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Lactate dehydrogenase A (LDHA) is an important glycolytic enzyme that promotes glycolysis and plays a crucial role in cancer cell invasion and immune infiltration. However, the relevance of LDHA in colon adenocarcinoma (COAD) remains unclear. In this study, we analyzed the correlation between the expression of LDHA and clinicopathological characteristics in COAD using immunohistochemistry analysis, and then used integrative bioinformatics analyses to further study the function and role of LDHA in COAD. We found that LDHA was highly expressed in COAD tissues compared with adjacent normal tissues, and that COAD patients with high LDHA expression levels showed poor survival. In addition, LDHA expression was closely associated with the immune infiltrating levels of CD8+ T cells, neutrophils, and dendritic cells. Our findings highlight the potential role of LDHA in the tumorigenesis and prognosis of COAD. Furthermore, our results indicate that COAD is a novel immune checkpoint in the diagnosis and treatment of COAD.

Keywords: LDHA; colon adenocarcinoma; therapy; tumor immune; tumor metabolism.