The effects of total enteral nutrition via nasal feeding and percutaneous radiologic gastrostomy in patients with dysphagia following a cerebral infarction

Tianwen Yuan; Guoqing Zeng; Qi Yang; Yang He; Peng Kong; Saibo Wang; Xing Zhou; Jun Cao

The effects of total enteral nutrition via nasal feeding and percutaneous radiologic gastrostomy in patients with dysphagia following a cerebral infarction

Am J Transl Res. 2021 Jun 15;13(6):6352-6361. eCollection 2021.

Authors

Tianwen Yuan¹, Guoqing Zeng², Qi Yang³, Yang He¹, Peng Kong¹, Saibo Wang¹, Xing Zhou¹, Jun Cao¹

Affiliations

¹ Department of Interventional Oncology, Dahua Hospital Xuhui District, Shanghai 200237, China.
² Department of Internal Medicine Community Health Service Center of Huajing Street Xuhui District, Shanghai 200237, China.
³ Department of Internal Medicine Community Health Service Center of Tianlin Street Xuhui District, Shanghai 200237, China.

PMID: 34306374
PMCID: PMC8290671

Abstract

Objective: To explore the effects of total enteral nutrition (TEN) via nasal feeding and percutaneous radiologic gastrostomy (PRG) on the nutritional status, quality of life, and prognosis in long-term bedridden patients with dysphagia after cerebral infarction.

Methods: One hundred and sixty long-term bedridden patients with dysphagia after cerebral infarction were randomly divided into a control group (CG, n=80) and an observation group (OG, n=80). The CG was administered TEN via nasal feeding, and the OG was administered TEN via PRG. The two groups' results were compared.

Results: The Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores in the OG were lower than the corresponding scores in the CG at 3 and 6 months after the TEN (P < 0.05). The OG had a higher proportion of high compliance, but a lower proportion of both moderate and low compliance than the CG (P < 0.05). The total incidence of TEN intolerance was 8.75% in the OG, lower than the 20.00% in the CG (P < 0.05). The AST, ALB, ALT, TBIL, Scr, and BUN levels showed no significant differences between the OG and the CG at 3 and 6 months after the TEN (P > 0.05). The IgM, IgG, IgA, hemoglobin, total protein, albumin, and transferrin levels showed no significant differences between the OG and the CG at 3 and 6 months after the TEN (P > 0.05). The incidence of catheterization complications was 20.00% in the OG, higher than the 8.75% in the CG (P < 0.05). The OG had higher SF-36 scores than the CG at 6 months after the TEN (P < 0.05).

Conclusion: Both nasal feeding and TEN via PRG can effectively improve patients' nutritional status, enhance their immune function, and improve their liver and renal function, but TEN after PRG is more effective at reducing intolerance and promoting quality of life in long-term bedridden patients with dysphagia after cerebral infarction. However, TEN after PRG will also increase the occurrence of recent complications, complications that should get additional clinical attention.

Keywords: Cerebral infarction; dysphagia; long-term bedridden patients; nasal feeding; percutaneous radiologic gastrostomy; prognosis; total enteral nutrition.