Association between Anemia and Risk of Parkinson Disease

Yao-Chin Wang; Abel Po-Hao Huang; Sheng-Po Yuan; Chu-Ya Huang; Chieh-Chen Wu; Tahmina Nasrin Poly; Suleman Atique; Woon-Man Kung

doi:10.1155/2021/8360627

Association between Anemia and Risk of Parkinson Disease

Behav Neurol. 2021 Jul 7:2021:8360627. doi: 10.1155/2021/8360627. eCollection 2021.

Authors

Yao-Chin Wang^{1

2}, Abel Po-Hao Huang³, Sheng-Po Yuan^{4

5

6}, Chu-Ya Huang⁷, Chieh-Chen Wu⁸, Tahmina Nasrin Poly⁴, Suleman Atique⁹, Woon-Man Kung⁸

Affiliations

¹ Department of Emergency, Min-Sheng General Hospital, Taoyuan, Taiwan.
² Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan.
³ Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
⁴ Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
⁵ Department of Otorhinolaryngology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
⁶ Department of Otorhinolaryngology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁷ Taiwan College of Healthcare Executives, Taipei, Taiwan.
⁸ Department of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei, Taiwan.
⁹ Department of Health Informatics, College of Public Health and Health Informatics, University of Ha'il, Ha'il, Saudi Arabia.

Abstract

Methods: We systematically searched articles on electronic databases such as PubMed, Embase, Scopus, and Google Scholar between January 1, 2000 and July 30, 2020. Articles were independently evaluated by two authors. We included observational studies (case-control and cohort) and calculated the risk ratios (RRs) for associated with anemia and PD. Heterogeneity among the studies was assessed using the Q and I ² statistic. We utilized the random-effect model to calculate the overall RR with 95% CI.

Results: A total of 342 articles were identified in the initial searches, and 7 full-text articles were evaluated for eligibility. Three articles were further excluded for prespecified reasons including insufficient data and duplications, and 4 articles were included in our systematic review and meta-analysis. A random effect model meta-analysis of all 4 studies showed no increased risk of PD in patients with anemia (N = 4, RR_adjusted = 1.17 (95% CI: 0.94-1.45, p = 0.15). However, heterogeneity among the studies was significant (I ² = 92.60, p = <0.0001). The pooled relative risk of PD in female patients with anemia was higher (N = 3, RR_adjusted = 1.14 (95% CI: 0.83-1.57, p = 0.40) as compared to male patients with anemia (N = 3, RR_adjusted = 1.09 (95% CI: 0.83-1.42, p = 0.51).

Conclusion: This is the first meta-analysis that shows that anemia is associated with higher risk of PD when compared with patients without anemia. However, more studies are warranted to evaluate the risk of PD among patients with anemia.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Anemia* / complications
Anemia* / epidemiology
Case-Control Studies
Cohort Studies
Female
Humans
Male
Parkinson Disease* / complications
Parkinson Disease* / epidemiology
Risk