Abstract
As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.
Copyright © 2021 Chang Liu et al.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Aging / genetics
-
Aging / physiology
-
Animals
-
Autophagy* / drug effects
-
Cisplatin / toxicity
-
Cochlea / blood supply
-
Cochlea / growth & development
-
Hair Cells, Auditory / metabolism
-
Hair Cells, Auditory / pathology
-
Hearing Loss, Noise-Induced
-
Hearing Loss, Sensorineural / etiology
-
Hearing Loss, Sensorineural / genetics
-
Hearing Loss, Sensorineural / metabolism
-
Hearing Loss, Sensorineural / prevention & control*
-
Humans
-
Insulin-Like Growth Factor I / physiology
-
Ischemia / physiopathology
-
Mice
-
Mice, Knockout
-
MicroRNAs / genetics
-
Oxidative Stress
-
Resveratrol / therapeutic use
-
Sleep Deprivation / complications
Substances
-
IGF1 protein, human
-
MicroRNAs
-
Insulin-Like Growth Factor I
-
Cisplatin
-
Resveratrol