Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling

Laia Cañes; Judith Alonso; Carme Ballester-Servera; Saray Varona; José R Escudero; Vicente Andrés; Cristina Rodríguez; José Martínez-González

doi:10.1161/HYPERTENSIONAHA.121.17517

Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling

Hypertension. 2021 Sep;78(3):681-692. doi: 10.1161/HYPERTENSIONAHA.121.17517. Epub 2021 Jul 26.

Authors

Laia Cañes^{1

2

3}, Judith Alonso^{1

2

3}, Carme Ballester-Servera^{1

2

3}, Saray Varona^{1

2

3}, José R Escudero⁴, Vicente Andrés⁵, Cristina Rodríguez^#^{2

3

6}, José Martínez-González^#^{1

2

3}

Affiliations

¹ Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Barcelona, Spain (L.C., J.A., C.B.-S., S.V., J.M.-G.).
² CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain (L.C., J.A., S.V., J.R.E., V.A., C.R., J.M.-G.).
³ Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain (L.C., J.A., C.B.-S., S.V., C.R., J.M.-G.).
⁴ Servicios Mancomunados de Angiología, Cirugía Vascular y Endovascular, Hospitales de la Santa Creu i Sant Pau/Dos de Mayo, Barcelona, Spain (J.R.E.).
⁵ Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.A.).
⁶ Institut de Recerca Hospital de la Santa Creu i Sant Pau (IRHSCSP), Barcelona, Spain (C.R.).

^# Contributed equally.

PMID: 34304581
DOI: 10.1161/HYPERTENSIONAHA.121.17517

Abstract

[Figure: see text].

Keywords: animals; aortic aneurysm; blood pressure; dopamine; tyrosine hydroxylase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta, Abdominal / metabolism*
Aortic Aneurysm, Abdominal / metabolism*
Apolipoproteins E / genetics
Apolipoproteins E / metabolism
Dopamine beta-Hydroxylase / metabolism
Humans
Inflammation / metabolism*
Mice
Mice, Knockout
Norepinephrine Plasma Membrane Transport Proteins / metabolism
Oxidative Stress / physiology*
Tyrosine 3-Monooxygenase / metabolism*
Vascular Remodeling / physiology*

Substances

Apolipoproteins E
Norepinephrine Plasma Membrane Transport Proteins
Tyrosine 3-Monooxygenase
Dopamine beta-Hydroxylase