[Research progress on the protective mechanism of insulin like growth factor-1 on inner ear]

Abstract

As one of the neurotrophic factors and insulin family, insulin like growth factor-1（IGF-1） can promote cell synthesis and metabolism in tissues and organs, activate cell growth, proliferation and differentiation, and inhibit cell apoptosis. Sensorineural hearing loss is the most common manifestation of the inner ear disease, which is mainly caused by the damage of cochlear hair cells. The lack of IGF-1 directly affects the growth, development and differentiation of cochlear hair cells, thus IGF-1 participates in the maintenance of cell survival and repair during inner ear cell injury. This article systematically reviews the recent research progress on the protective mechanism of IGF-1 on the inner ear.

Keywords: hair cell; insulin like growth factor-1; sensorineural hearing loss; spiral ganglion.