Synthesis of charged chitosan nanoparticles as functional biolubricant

Lumin Yang; Xiaoduo Zhao; Jing Zhang; Shuanhong Ma; Lei Jiang; Qiangbing Wei; Meirong Cai; Feng Zhou

doi:10.1016/j.colsurfb.2021.111973

Synthesis of charged chitosan nanoparticles as functional biolubricant

Colloids Surf B Biointerfaces. 2021 Oct:206:111973. doi: 10.1016/j.colsurfb.2021.111973. Epub 2021 Jul 15.

Authors

Lumin Yang¹, Xiaoduo Zhao¹, Jing Zhang², Shuanhong Ma³, Lei Jiang², Qiangbing Wei⁴, Meirong Cai¹, Feng Zhou⁵

Affiliations

¹ State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
² Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences/Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Xining, 810008, China.
³ State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. Electronic address: mashuanhong@licp.cas.cn.
⁴ Key Laboratory of Eco-Environmental-Related Polymer Materials, Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
⁵ State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. Electronic address: zhouf@licp.cas.cn.

PMID: 34303997
DOI: 10.1016/j.colsurfb.2021.111973

Abstract

Osteoarthritis has been a major disease in recent years, which is mainly related to the breakdown of the lubrication function of the cartilage sliding interface, along with the inflammation of the joint capsule. In this paper, one kind of novel biomimetic nanoparticles (NPs) lubricant, named CS-PS, is synthesized through chemically grafting hydrophilic sulfonic acid (SO₃^-) groups onto the surface of biocompatible and biodegradable chitosan (CS) NPs. Compared with control CS NPs, the as-synthesized CS-PS NPs exhibits excellent hydration and stability because of negatively charged surface zeta potential, along with extraordinary lubrication performance in water for realizing a super-low friction coefficient (COF) as ∼0.01 at the sliding interface of PDMS elastomer-Ti₆Al₄V disk. Correspondingly, the CS-PS NPs can also be used as a drug carrier for aspirin, which presents very good drug loading and release behavior in PBS (pH = 7.4). MCS cells culture experiment proves that this kind of novel lubricant is nontoxic and biocompatible, for which may be expected to use as potential articular injective material for the treatment of osteoarthritis.

Keywords: Drug release; Nanoparticles; Osteoarthritis; Surface modification; Water lubrication.

MeSH terms

Chitosan*
Drug Carriers
Friction
Lubrication
Nanoparticles*

Substances

Drug Carriers
Chitosan