Phytonanomaterials as therapeutic agents and drug delivery carriers

Ying Xie; Chao Ma; Xin Yang; Jiacheng Wang; Gretchen Long; Jiangbing Zhou

doi:10.1016/j.addr.2021.113868

Phytonanomaterials as therapeutic agents and drug delivery carriers

Adv Drug Deliv Rev. 2021 Sep:176:113868. doi: 10.1016/j.addr.2021.113868. Epub 2021 Jul 22.

Authors

Ying Xie¹, Chao Ma², Xin Yang³, Jiacheng Wang⁴, Gretchen Long¹, Jiangbing Zhou⁵

Affiliations

¹ Department of Neurosurgery, Yale University, New Haven, CT 06510, USA.
² College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China.
³ School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China.
⁴ School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China.
⁵ Department of Neurosurgery, Yale University, New Haven, CT 06510, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA. Electronic address: jiangbing.zhou@yale.edu.

Abstract

Medicinal plants have been a major resource for drug discovery. Emerging evidence shows that in addition to pharmacologically active components, medicinal plants also contain phytochemical nanomaterials, or phytonanomaterials, which form nanoparticles for drug delivery. In this review, we examine the evidence supporting the existence of phytonanomaterials. Next, we review identification, isolation, and classification of phytonanomaterials, characteristics of phytonanomaterial-derived nanoparticles, and molecular mechanisms of phytonanomaterial assembly. We will then summarize the current progress in exploring phytonanomaterial-derived NPs as therapeutic agents and drug delivery carriers for disease treatment. Last, we will provide perspectives on future discovery and applications of phytonanomaterials.

Keywords: Drug delivery; Medicinal plants; Nanoparticles; Nanostructural assembly; Phytonanomaterials.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Delivery Systems*
Humans
Nanostructures / administration & dosage*
Phytochemicals / administration & dosage*

Substances

Phytochemicals

Grants and funding

R01 NS110721/NS/NINDS NIH HHS/United States