Metastatic colorectal cancer: Perspectives on long non-coding RNAs and promising therapeutics

Chunyuan Tang; Junqing Liu; Qingqing Hu; Su Zeng; Lushan Yu

doi:10.1016/j.ejphar.2021.174367

Metastatic colorectal cancer: Perspectives on long non-coding RNAs and promising therapeutics

Eur J Pharmacol. 2021 Oct 5:908:174367. doi: 10.1016/j.ejphar.2021.174367. Epub 2021 Jul 22.

Authors

Chunyuan Tang¹, Junqing Liu², Qingqing Hu³, Su Zeng¹, Lushan Yu⁴

Affiliations

¹ Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
² The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310022, China.
³ The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Jinhua, 322023, China.
⁴ Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: yuls@zju.edu.cn.

PMID: 34303661
DOI: 10.1016/j.ejphar.2021.174367

Abstract

Metastatic colorectal cancer (mCRC) has long been lethal despite the continuous efforts of researchers worldwide to discover and improve therapeutic regimens. Thanks to the emergence of long non-coding RNAs (lncRNAs), which has strongly reshaped our inherent perspectives on the pathophysiological patterns of disease, research in the field has been reinvigorated. Here, we focus on current understanding of the modes of action of lncRNAs, and review their regulatory roles in metastatic colorectal cancer, and discuss correlated potential lncRNA-based therapeutics. All of the discussed studies share clear and promising perspectives on future diagnostic and therapeutic remedies for metastatic colorectal cancer.

Keywords: Colorectal cancer; Mechanism; Metastasis; lncRNAs.

Publication types

Review

MeSH terms

Colorectal Neoplasms*
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs
RNA, Long Noncoding

Substances

MicroRNAs
RNA, Long Noncoding