Prospective antibacterial inhibition of c-type cytochrome synthesis

Abstract

Sutherland et al. recently reported the in vitro inhibition of Helicobacter hepaticus cytochrome c (cyt c) synthase, which may inactivate c-type cytochromes in this and in other pathogenic bacteria. Here, I discuss the impact of this work, which identifies this conserved synthase as a potential antibacterial target.

Keywords: antibacterial strategy; c-type cytochrome; cytochrome c; cytochrome c synthase; heme attachment; peptide.