Chronic deep brain stimulation reduces cortical β-γ phase amplitude-coupling in patients with Parkinson's disease

Katsuki Eguchi; Shinichi Shirai; Masaaki Matsushima; Takahiro Kano; Tomohiro Ichikawa; Kazuyoshi Yamazaki; Shuji Hamauchi; Toru Sasamori; Toshitaka Seki; Mayumi Kitagawa; Hideaki Shiraishi; Kiyohiro Houkin; Hidenao Sasaki; Ichiro Yabe

doi:10.1016/j.parkreldis.2021.07.017

Chronic deep brain stimulation reduces cortical β-γ phase amplitude-coupling in patients with Parkinson's disease

Parkinsonism Relat Disord. 2021 Aug:89:148-150. doi: 10.1016/j.parkreldis.2021.07.017. Epub 2021 Jul 16.

Authors

Affiliations

¹ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: k198762@gmail.com.
² Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: shirai@med.hokudai.ac.jp.
³ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: mmasaaki@huhp.hokudai.ac.jp.
⁴ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: tk76@hotmail.co.jp.
⁵ Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Japan. Electronic address: t.ichikawa@huhp.hokudai.ac.jp.
⁶ Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: mt.kazu71@gmail.com.
⁷ Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: hamashuji@yahoo.co.jp.
⁸ Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital, 1-40, Kita 22, Higashi 1, Higashi-ku, Sapporo, 065-0022, Japan. Electronic address: mo_ri25@yahoo.co.jp.
⁹ Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: tseki@med.hokudai.ac.jp.
¹⁰ Sapporo Teishinkai Hospital, Kita 33, Higashi 1, Higashi-ku, Sapporo, 065-0033, Japan. Electronic address: mkitagawa@ab.inbox.ne.jp.
¹¹ Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: siraisi@med.hokudai.ac.jp.
¹² Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: houkin@med.hokudai.ac.jp.
¹³ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: h-isasak@med.hokudai.ac.jp.
¹⁴ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: yabe@med.hokudai.ac.jp.

PMID: 34303200
DOI: 10.1016/j.parkreldis.2021.07.017

Abstract

We compared β-γ phase amplitude coupling (PAC) before and one year after chronic deep brain stimulation (DBS) in patients with Parkinson's disease using EEG and observed significant post-operative reduction of PAC values. Our findings suggest that the reduction in PAC due to DBS can be observed after chronic stimulation, which is not a transient phenomenon just after the start of DBS.

Keywords: Deep brain stimulation; Electroencephalogram; Parkinson's disease; Phase amplitude coupling.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Beta Rhythm / physiology*
Deep Brain Stimulation*
Dopamine Agents / therapeutic use
Electroencephalography
Female
Gamma Rhythm / physiology*
Humans
Male
Middle Aged
Parkinson Disease / physiopathology*
Parkinson Disease / therapy*
Postoperative Period
Subthalamic Nucleus / physiopathology
Time Factors
Treatment Outcome

Substances

Dopamine Agents