Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents

Parasitol Int. 2021 Dec:85:102424. doi: 10.1016/j.parint.2021.102424. Epub 2021 Jul 22.

Abstract

179 compounds in a Mongolian compound library were investigated for their inhibitory effect on the in vitro growth of Plasmodium falciparum and Toxoplasma gondii. Among these compounds, brachangobinan A at a half-maximal inhibition concentration (IC50) of 2.62 μM and a selectivity index (SI) of 27.91; 2-(2'-hydroxy-5'-O-methylphenyl)-5-(2″,5″-dihydroxyphenyl)oxazole (IC50 3.58 μM and SI 24.66); chrysosplenetin (IC50 3.78 μM and SI 15.26); 4,11-di-O-galloylbergenin (IC50 3.87 μM and SI 13.38); and 2-(2',5'-dihydroxyphenyl)-5-(2″-hydroxyphenyl)oxazole (IC50 6.94 μM and SI 11.48) were identified as potential inhibitors of P. falciparum multiplication. Additionally, tricin (IC50 12.94 μM and SI > 23.40) was identified as a potential inhibitor of T. gondii multiplication. Our findings represent a good starting point for developing novel antimalarial and anti-Toxoplasma therapeutics from Mongolian compounds.

Keywords: Malaria; Mongolian compound library; Plasmodium falciparum; Toxoplasma gondii; Toxoplasmosis.

MeSH terms

  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Coccidiostats / chemistry
  • Coccidiostats / pharmacology*
  • Inhibitory Concentration 50
  • Mongolia
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*
  • Toxoplasma / drug effects*

Substances

  • Antimalarials
  • Coccidiostats
  • Plant Extracts