Total Synthesis of Pagoamide A

Fusong Wu; Jie Yu; Jiawei Meng; Yian Guo; Tao Ye

doi:10.3390/molecules26144224

Total Synthesis of Pagoamide A

Molecules. 2021 Jul 12;26(14):4224. doi: 10.3390/molecules26144224.

Authors

Fusong Wu¹, Jie Yu¹, Jiawei Meng¹, Yian Guo^{1

2}, Tao Ye¹

Affiliations

¹ State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
² School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.

Abstract

The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.

Keywords: cyclic depsipeptides; pagoamide A; total synthesis.

MeSH terms

Depsipeptides / chemical synthesis*
Molecular Structure
Peptides, Cyclic / chemical synthesis*
Thiazoles / chemistry

Substances

Depsipeptides
Peptides, Cyclic
Thiazoles