Ultrastructure of Endothelial Cells of Myocardial Capillaries in Burn Septicotoxemia

Bull Exp Biol Med. 2021 Jul;171(3):393-398. doi: 10.1007/s10517-021-05235-y. Epub 2021 Jul 23.

Abstract

We studied ultrastructure and vesicular structures in endothelial cells of myocardial micro-vessels in burn patients. Electron microscopy revealed a significant decrease in volume density of vesicular structures in the endotheliocytes of myocardial capillaries in patients with burn septicotoxemia. The observed structural signs of endothelial dysfunction revealed in this category of patients can be a promising area for further research and for the development of methods of pathogenetic correction of myocardial disorders in the case of burn injury.

Keywords: burn injury; endothelial dysfunction; injury of myocardium; septicotoxemia; transport vesicles.

MeSH terms

  • Adult
  • Autopsy
  • Burns / complications
  • Burns / pathology*
  • Capillaries / pathology
  • Capillaries / ultrastructure*
  • Caveolae / pathology
  • Caveolae / ultrastructure
  • Endothelial Cells / pathology
  • Endothelial Cells / ultrastructure*
  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Myocardium / pathology
  • Myocardium / ultrastructure*
  • Sepsis / complications
  • Sepsis / pathology*
  • Transport Vesicles / pathology
  • Transport Vesicles / ultrastructure