Neurotrophic Effect of Magnesium Comenate in Normal and under Conditions of Oxidative Stress in Culture of Chicken Spinal Ganglia

L V Shurygina; E I Zlishcheva; A A Kravtsov; S V Kozin

doi:10.1007/s10517-021-05223-2

Neurotrophic Effect of Magnesium Comenate in Normal and under Conditions of Oxidative Stress in Culture of Chicken Spinal Ganglia

Bull Exp Biol Med. 2021 Jul;171(3):338-341. doi: 10.1007/s10517-021-05223-2. Epub 2021 Jul 23.

Authors

L V Shurygina¹, E I Zlishcheva¹, A A Kravtsov^{2

3}, S V Kozin^{1

4}

Affiliations

¹ A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia.
² A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia. aakravtsov@mail.ru.
³ Laboratory for Problems of Distribution of Stable Isotopes in Living Systems, Federal Research Center South Scientific Center of the Russian Academy of Sciences, Krasnodar, Russia. aakravtsov@mail.ru.
⁴ Laboratory for Problems of Distribution of Stable Isotopes in Living Systems, Federal Research Center South Scientific Center of the Russian Academy of Sciences, Krasnodar, Russia.

PMID: 34297285
DOI: 10.1007/s10517-021-05223-2

Abstract

The neurotrophic properties of magnesium comenate were studied under standard conditions and under conditions of oxidative stress. It was found that magnesium comenate has a stimulating effect on the neurotrophic processes of the spinal ganglia under normal conditions and under conditions of oxidative stress. Under standard conditions, magnesium comenate exhibits neurotrophic activity at a concentration of 0.0001 mM, under conditions of oxidative stress, magnesium comenate exhibits neurotrophic activity at concentration 0.1 mM.

Keywords: magnesium comenate; neurite growth; neurotrophic activity; oxidative stress; spinal ganglia.

MeSH terms

Animals
Carboxylic Acids / pharmacology*
Chick Embryo
Ganglia, Spinal / drug effects*
Ganglia, Spinal / metabolism
Hydrogen Peroxide / antagonists & inhibitors
Hydrogen Peroxide / pharmacology
Magnesium Compounds / pharmacology*
Neuronal Outgrowth / drug effects*
Neuroprotective Agents / pharmacology*
Oxidative Stress
Pyrones / pharmacology*
Tissue Culture Techniques

Substances

Carboxylic Acids
Magnesium Compounds
Neuroprotective Agents
Pyrones
comenic acid
Hydrogen Peroxide