SARS-CoV-2 Infection Causes Relapse of Kleine-Levin Syndrome: Case Report and Review of Literature

Marino Marčić; Ljiljana Marčić; Barbara Marčić

doi:10.3390/neurolint13030033

SARS-CoV-2 Infection Causes Relapse of Kleine-Levin Syndrome: Case Report and Review of Literature

Neurol Int. 2021 Jul 20;13(3):328-334. doi: 10.3390/neurolint13030033.

Authors

Marino Marčić¹, Ljiljana Marčić², Barbara Marčić³

Affiliations

¹ Department of Neurology, University Hospital Center Split, Spinčićeva1, 21000 Split, Croatia.
² Department of Radiology, Polyclinic Medikol, 21000 Split, Croatia.
³ Department of Histology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.

Abstract

Recurrent episodes of hypersomnia, hypersexuality, compulsive eating, behavioral and cognitive disturbances, are the basic clinical features of Kleine-Levin syndrome (KLS). Our case report describes a patient who was diagnosed with KLS at the age of 20. With appropriate therapy, the disease had a satisfactory course until patient had a moderate form of SARS-CoV-2 infection, which led to a significant exacerbation of all symptoms. SARS-CoV-2 virus can cause almost any neurological disease, and relapse of KLS is another evidence of neurotropicity of the virus.

Keywords: Kleine-Levin; SARS-CoV-2; hyperphagia; hypersomnia.

Publication types

Case Reports