Dual-drug delivery system based on the hydrogels of alginate and sodium carboxymethyl cellulose for colorectal cancer treatment

Abstract

To improve the efficacy of chemotherapy and relieve the pain associated with colorectal cancer, a dual-drug delivery system (DDDS) is proposed. In this system, methotrexate (MTX) loaded CaCO₃ (CaCO₃/MTX) and aspirin (Asp) are co-entrapped in the hydrogels of alginate (Alg) and sodium carboxymethyl cellulose (CMC) crosslinked with Ca²⁺. The hydrogels can protect the anti-cancer drug of MTX from being absorbed in stomach and small intestine and ensure their efficacy at the target site of colorectum. More importantly, dual pH-responsive drug delivery can be achieved by the DDDS. Because the pH varies at small intestine and colorectum of human body, dual pH-responsive delivery of Asp and MTX can be achieved at the two organs, respectively, in response to ambient pH. These finding are of significant importance for medical science and pharmaceutics.

Keywords: Alginate; Calcium carbonate microspheres; Dual pH-sensitivity; Dual-drug delivery system; Sodium carboxymethyl cellulose.