Large carnivore attacks on humans are a serious form of human-wildlife interaction which has increased globally in recent decades. When attacks occur, both humans and large carnivores suffer, highlighting the need to characterize these conflicts toward mitigation of attacks. We investigated brown bear (Ursus arctos) and Persian leopard (Panthera pardus) attacks on humans across Iran using reports provided by the Government of Iran during 2012-2020. We characterized temporal and spatial patterns of attacks, as well as species-specific attributes. We identified 83 attacks resulting in 77 human injuries and 6 fatalities. Bears were responsible for more attacks (63%) than leopards (37%). Attacks occurred more frequently during defensive reactions by bears and leopards on adult male people while livestock herding during the day in spring and summer. Bears reportedly attacked people more often in western provinces of Iran, while leopards attacked more frequently in northern provinces. We recommend that the Iran Department of the Environment consider implementing a national reporting system to document bear and leopard attacks on people. We further suggest development of national bear and leopard management plans that emphasize mitigating human risk to improve human attitudes toward these carnivore species to facilitate their conservation.