Liver Involvement in Congenital Disorders of Glycosylation and Deglycosylation

Patryk Lipiński; Anna Bogdańska; Piotr Socha; Anna Tylki-Szymańska

doi:10.3389/fped.2021.696918

Liver Involvement in Congenital Disorders of Glycosylation and Deglycosylation

Front Pediatr. 2021 Jul 5:9:696918. doi: 10.3389/fped.2021.696918. eCollection 2021.

Authors

Patryk Lipiński¹, Anna Bogdańska², Piotr Socha³, Anna Tylki-Szymańska¹

Affiliations

¹ Department of Pediatrics, Nutrition and Metabolic Diseases, Children's Memorial Health Institute, Warsaw, Poland.
² Department of Biochemistry, Radioimmunology and Experimental Medicine, Children's Memorial Health Institute, Warsaw, Poland.
³ Department of Gastroenterology, Hepatology, Feeding Difficulties and Pediatrics, Children's Memorial Health Institute, Warsaw, Poland.

Abstract

Background: Congenital disorders of glycosylation (CDG) and NGLY1-CDDG (NGLY1-congenital disorder of deglycosylation) usually represent multisystem (especially neurovisceral) diseases with liver involvement reported in some of them. The aim of the study was to characterize the liver phenotype in CDG and NGLY1-CDDG patients hospitalized in our Institute, and to find the most specific features of liver disease among them. Material and Methods: The study involved 39 patients (from 35 families) with CDG, and two patients (from two families) with NGLY1-CDDG, confirmed molecularly, for whom detailed characteristics of liver involvement were available. They were enrolled based on the retrospective analysis of their medical records. Results: At the time of the first consultation, 13/32 patients were diagnosed with hepatomegaly; none of them with splenomegaly. As many as 23/32 persons had elevated serum transaminases, including 16 (70%) who had mildly elevated levels. During the long-term follow-up (available for 19 patients), serum transaminases normalized in 15/19 (79%) of them, including a spontaneous normalization in 12/15 (80%) of them. The GGT activity was observed to be normal in all study cases. Protein C, protein S and antithrombin activities in plasma were observed in 16 patients, and they were decreased in all of them. Conclusions: It is necessary to conduct a long-term follow-up of liver disease in CDG to obtain comprehensive data.

Keywords: NGLY1-conegnital disorder of deglycosylation; coagulopathy; congenital disorder glycosylation; elevated serum transaminases; hepatomegaly; liver disease.