Abstract
Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. Recent molecular studies have revealed the existence of multiple, distinct mechanisms of Aurora A activation, each occurring at specific subcellular locations, optimized for cellular context, and primed by signaling events including phosphorylation and oxidation.
© 2021 Tavernier et al.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allosteric Regulation
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Animals
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Aurora Kinase A / genetics*
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Aurora Kinase A / metabolism
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Cell Cycle Proteins / genetics*
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Cell Cycle Proteins / metabolism
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Eukaryotic Cells / cytology
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Eukaryotic Cells / enzymology
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Humans
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Microtubule-Associated Proteins / genetics*
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Microtubule-Associated Proteins / metabolism
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Microtubules / metabolism
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Microtubules / ultrastructure
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Mitosis*
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Oxidation-Reduction
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Phosphorylation
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Protein Binding
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Protein Processing, Post-Translational*
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Signal Transduction
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Spindle Apparatus / metabolism
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Spindle Apparatus / ultrastructure
Substances
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Cell Cycle Proteins
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Microtubule-Associated Proteins
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TPX2 protein, human
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bora protein, human
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AURKA protein, human
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Aurora Kinase A