The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10

Isabel Abánades Lázaro; Jose M Rodrigo-Muñoz; Beatriz Sastre; María Romero Ángel; Carlos Martí-Gastaldo; Victoria Del Pozo

doi:10.1039/d1tb00981h

The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10

J Mater Chem B. 2021 Aug 21;9(31):6144-6148. doi: 10.1039/d1tb00981h. Epub 2021 Jul 20.

Authors

Isabel Abánades Lázaro¹, Jose M Rodrigo-Muñoz, Beatriz Sastre, María Romero Ángel, Carlos Martí-Gastaldo, Victoria Del Pozo

Affiliation

¹ Instituto de Ciencia Molecular (ICMol), Universitat de València, Catedrático José Beltrán Martínez no. 2, Paterna 46980, Valencia, Spain. Isabel.abanades@uv.es.

PMID: 34286816
DOI: 10.1039/d1tb00981h

Abstract

The Ti-Ca heterometallic MOF MUV-10 exhibits good dispersibility in phosphate buffer and low phosphate-induced degradation in comparison to other MOF systems. It induces no cytotoxicity towards cells of the immune system and no inmune response, making it an attractive candidate for biomedical applications and demonstrating its safe use for other applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry*
Calcium / chemistry*
Humans
Immunity
Materials Testing
Metal-Organic Frameworks / chemical synthesis
Metal-Organic Frameworks / chemistry*
Mice
Particle Size
Titanium / chemistry*

Substances

Biocompatible Materials
Metal-Organic Frameworks
Titanium
Calcium