A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy

Chem Commun (Camb). 2021 Aug 10;57(64):7954-7957. doi: 10.1039/d1cc02629a.

Abstract

Herein, we report, for the first time, a Pd6L8(NO3)5.4(ICG)6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate (3) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1O2 generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Infrared Rays
  • MCF-7 Cells
  • Metal-Organic Frameworks / chemistry
  • Metal-Organic Frameworks / pharmacology*
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Particle Size
  • Photochemotherapy
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*

Substances

  • Antineoplastic Agents
  • Metal-Organic Frameworks
  • Photosensitizing Agents