Objective: To investigate the prognosis of two rare imported patients with human African trypanosomias (HAT) after treatment in a follow-up study, and to evaluate the therapeutic efficacy, so as to provide insights into the treatment of imported HAT patients.
Methods: The white blood cells in cerebrospinal fluid samples and the trypomastigotes in cerebrospinal fluid and blood samples were monitored in an imported case with Trypanosoma brucei rhodesiense infection 1, 3, 11 and 25 months post-treatment and in an imported case with T. brucei gambiense infection 1, 3, 8 and 12 months post-treatment to evaluate the therapeutic efficacy and prognosis.
Results: There were 1, 1, 4 and 2 white blood cells in per μL of cerebrospinal fluid in the case with T. brucei rhodesiense infection 1, 3, 11 and 25 months post-treatment, and there were 3, 6, 4 and 3 white blood cells in per μL of cerebrospinal fluid in the case with T. brucei gambiense infection 1, 3, 8 and 12 months post-treatment. In addition, no trypomastigotes were identified in the cerebrospinal fluid or blood samples of either case with T. brucei rhodesiense or T. brucei gambiense infection.
Conclusions: Following standardized treatment, two imported cases with human African trypanosomiasis cases recover satisfactorily, without any signs of relapse.
［摘要］ 目的 对2例罕见的输入性非洲锥虫病 (human african trypanosomiasis, HAT) 病例治疗后进行随访研究, 评判治 疗效果, 从而为输入性锥虫病临床治疗提供参考依据。方法 1例输入性罗德西锥虫病病例在治疗完成后第1、3、11、25 个月以及1例输入性冈比亚锥虫病病例在治疗完成后第1、3、8、12个月, 分别检测患者脑脊液中白细胞计数及脑脊液和 血液中锥鞭毛体, 比较治疗时、治疗后生理生化指标变化, 根据其检测结果进行治疗效果和预后评判。结果 罗德西亚 锥虫病病例在治疗后第1、3、11、25个月, 脑脊液中白细胞计数分别为1、1、4、2个/μL; 冈比亚锥虫病病例在治疗后第1、 3、8、12个月, 脑脊液中白细胞计数分别为3、6、4、3个/μL。2例病例在随访中均未在脑脊液和血液中查见锥鞭毛体。结论 经过规范治疗, 2例输入性锥虫病病例恢复良好, 没有复发迹象。.
Keywords:
Human African trypanosomiasis; Prognosis;