Hyperphosphatemic Tumoral Calcinosis

Excerpt

Hyperphosphatemic tumoral calcinosis (HTC), also known as hyperphosphatemic familial tumoral calcinosis or familial tumoral calcinosis/hyperostosis hyperphosphatemia syndrome, is a disorder of phosphate regulation. It is a rare disabling disorder manifesting as ectopic calcifications in periarticular regions and thereby causing limitation in joint motions and disability. Besides, inflammatory bony pains are also a peculiar feature of this disorder. Due to the extreme rarity of the disease and lack of clinical trials, the evidence regarding various management options is not robust. The management options include phosphate-lowering therapies, anti-inflammatory medications, and surgical excision of the calcific masses with significantly disabled cases.