Obstetric hemorrhage risk assessment tool predicts composite maternal morbidity

Sci Rep. 2021 Jul 19;11(1):14709. doi: 10.1038/s41598-021-93413-3.

Abstract

Obstetric hemorrhage is one of the leading preventable causes of maternal mortality in the United States. Although hemorrhage risk-prediction models exist, there remains a gap in literature describing if these risk-prediction tools can identify composite maternal morbidity. We investigate how well an established obstetric hemorrhage risk-assessment tool predicts composite hemorrhage-associated morbidity. We conducted a retrospective cohort analysis of a multicenter database including women admitted to Labor and Delivery from 2016 to 2018, at centers implementing the Association of Women's Health, Obstetric, and Neonatal Nurses risk assessment tool on admission. A composite morbidity score incorporated factors including obstetric hemorrhage (estimated blood loss ≥ 1000 mL), blood transfusion, or ICU admission. Out of 56,903 women, 14,803 (26%) were categorized as low-risk, 26,163 (46%) as medium-risk and 15,937 (28%) as high-risk for obstetric hemorrhage. Composite morbidity occurred at a rate of 2.2%, 8.0% and 11.9% within these groups, respectively. Medium- and high-risk groups had an increased combined risk of composite morbidity (diagnostic OR 4.58; 4.09-5.13) compared to the low-risk group. This established hemorrhage risk-assessment tool predicts clinically-relevant composite morbidity. Future randomized trials in obstetric hemorrhage can incorporate these tools for screening patients at highest risk for composite morbidity.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Blood Transfusion / statistics & numerical data
  • Cohort Studies
  • Databases, Factual / statistics & numerical data
  • Delivery, Obstetric / adverse effects
  • Female
  • Humans
  • Models, Statistical*
  • Morbidity
  • Obstetric Labor Complications / diagnosis
  • Obstetric Labor Complications / epidemiology
  • Postpartum Hemorrhage / diagnosis*
  • Postpartum Hemorrhage / epidemiology*
  • Postpartum Hemorrhage / therapy
  • Pregnancy
  • Prognosis
  • Puerperal Disorders / diagnosis
  • Puerperal Disorders / epidemiology
  • Research Design
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • United States / epidemiology