Statins for Prostate Cancer: When and How Much?

Clin Cancer Res. 2021 Sep 15;27(18):4947-4949. doi: 10.1158/1078-0432.CCR-21-1891. Epub 2021 Jul 19.

Abstract

Statins have plausible biological effects against prostate cancer cells and are associated with improved disease-specific mortality. In current randomized placebo-controlled trial, low-dose atorvastatin caused no difference in relapses after radical prostatectomy in Asian men. Future trials should study higher statin doses at later disease stages with survival as the endpoint.See related article by Jeong et al., p. 5004.

Publication types

  • Comment

MeSH terms

  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / adverse effects
  • Male
  • Neoplasm Recurrence, Local
  • Prostate-Specific Antigen
  • Prostatectomy
  • Prostatic Neoplasms* / drug therapy
  • Prostatic Neoplasms* / surgery

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Prostate-Specific Antigen