Simulated microgravity alters the expression of plasma SSAO and its enzymatic activity in healthy rats and increases the mortality in high-fat diet/streptozotocin-induced diabetes

Nino Rcheulishvili; Dimitri Papukashvili; Zixuan Deng; Shibo Wang; Yulin Deng

doi:10.1016/j.lssr.2021.04.002

Simulated microgravity alters the expression of plasma SSAO and its enzymatic activity in healthy rats and increases the mortality in high-fat diet/streptozotocin-induced diabetes

Life Sci Space Res (Amst). 2021 Aug:30:24-28. doi: 10.1016/j.lssr.2021.04.002. Epub 2021 Apr 27.

Authors

Nino Rcheulishvili¹, Dimitri Papukashvili¹, Zixuan Deng¹, Shibo Wang¹, Yulin Deng²

Affiliations

¹ School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
² School of Life Science, Beijing Institute of Technology, Beijing, 100081, China; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, Beijing, China. Electronic address: deng@bit.edu.cn.

PMID: 34281661
DOI: 10.1016/j.lssr.2021.04.002

Abstract

Semicarbazide-sensitive amine oxidase (SSAO) activity is known to be associated with certain pathologies including diabetes. In this study, SSAO expression and enzymatic activity in blood plasma of healthy rats were significantly upregulated under simulated microgravity (SMG) condition. Significant mortality was observed in SMG group of diabetic rats. Results indicate that microgravity might increase the risks of SSAO-associated alterations.

Keywords: SSAO; Simulated microgravity; diabetes; mortality.

MeSH terms

Amine Oxidase (Copper-Containing)*
Animals
Diabetes Mellitus, Experimental*
Diet, High-Fat / adverse effects
Plasma
Rats
Streptozocin
Weightlessness* / adverse effects

Substances

Streptozocin
Amine Oxidase (Copper-Containing)