The activity and selectivity of transcriptional enhancers determine gene expression patterns that enable a zygote to become a complex organism. How enhancers convey regulatory information is a central conundrum in biology. Here, we discuss recent progress provided by rapidly evolving technologies in understanding enhancer-promoter interactions in the context of overall nuclear genome organization.
Keywords: Chromatin looping; Enhancer RNAs; Enhancer-promoter interractions,; Genome organization; Transcription activation.
Published by Elsevier Ltd.