Abstract
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
Keywords:
chronic wounds; endogenous repair; multifunctional wound dressing; nanomedicine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Annexin A1 / administration & dosage*
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Anti-Inflammatory Agents / administration & dosage*
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Bandages*
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Biocompatible Materials / administration & dosage
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Biopolymers / chemistry
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Cell Survival / drug effects
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / complications*
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Follistatin-Related Proteins / administration & dosage*
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HaCaT Cells
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Humans
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Magnetic Iron Oxide Nanoparticles / chemistry
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Male
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Materials Testing / methods
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Mice
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Nanofibers / chemistry
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Peptides / administration & dosage*
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Rats
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Rats, Wistar
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Staphylococcal Infections / complications*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Surgical Wound / complications*
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Surgical Wound / drug therapy*
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Treatment Outcome
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Wound Healing / drug effects*
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Wound Infection / complications*
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Wound Infection / drug therapy*
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Wound Infection / microbiology
Substances
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Annexin A1
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Anti-Inflammatory Agents
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Biocompatible Materials
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Biopolymers
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Follistatin-Related Proteins
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Peptides
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annexin A1 peptide (2-26)