Abstract
Drug repurposing aims to find new uses for already existing and approved drugs. We now provide a brief overview of recent developments in drug repurposing using machine learning alongside other computational approaches for comparison. We also highlight several applications for cancer using kinase inhibitors, Alzheimer's disease as well as COVID-19.
Keywords:
Drug discovery; Drug repurposing; Machine learning.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Alzheimer Disease / drug therapy*
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Antineoplastic Agents / therapeutic use
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Antiviral Agents / therapeutic use
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COVID-19 Drug Treatment*
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Clemastine / pharmacology
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Computational Biology / methods
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Dipyridamole / pharmacology
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Drug Repositioning / trends*
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Humans
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Hydroxychloroquine / pharmacology
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Lenalidomide / pharmacology
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Machine Learning*
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Neoplasms / drug therapy*
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Neuroprotective Agents / therapeutic use
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Piperazines / pharmacology
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Piperidines / pharmacology
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Protein Kinase Inhibitors / pharmacology
Substances
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Antineoplastic Agents
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Antiviral Agents
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Neuroprotective Agents
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PB28 compound
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Piperazines
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Piperidines
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Protein Kinase Inhibitors
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Hydroxychloroquine
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Dipyridamole
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cloperastine
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Clemastine
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Lenalidomide