Recent advances in drug repurposing using machine learning

Curr Opin Chem Biol. 2021 Dec:65:74-84. doi: 10.1016/j.cbpa.2021.06.001. Epub 2021 Jul 16.

Abstract

Drug repurposing aims to find new uses for already existing and approved drugs. We now provide a brief overview of recent developments in drug repurposing using machine learning alongside other computational approaches for comparison. We also highlight several applications for cancer using kinase inhibitors, Alzheimer's disease as well as COVID-19.

Keywords: Drug discovery; Drug repurposing; Machine learning.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Antineoplastic Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • COVID-19 Drug Treatment*
  • Clemastine / pharmacology
  • Computational Biology / methods
  • Dipyridamole / pharmacology
  • Drug Repositioning / trends*
  • Humans
  • Hydroxychloroquine / pharmacology
  • Lenalidomide / pharmacology
  • Machine Learning*
  • Neoplasms / drug therapy*
  • Neuroprotective Agents / therapeutic use
  • Piperazines / pharmacology
  • Piperidines / pharmacology
  • Protein Kinase Inhibitors / pharmacology

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Neuroprotective Agents
  • PB28 compound
  • Piperazines
  • Piperidines
  • Protein Kinase Inhibitors
  • Hydroxychloroquine
  • Dipyridamole
  • cloperastine
  • Clemastine
  • Lenalidomide