The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils

Boyu An; Xiangyue Xu; Wenjin Ma; Meixia Huo; Hanyu Wang; Zhenli Liu; Guyue Cheng; Lingli Huang

doi:10.1016/j.ecoenv.2021.112503

The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils

Ecotoxicol Environ Saf. 2021 Oct 1:222:112503. doi: 10.1016/j.ecoenv.2021.112503. Epub 2021 Jul 14.

Authors

Boyu An¹, Xiangyue Xu¹, Wenjin Ma¹, Meixia Huo¹, Hanyu Wang², Zhenli Liu², Guyue Cheng³, Lingli Huang⁴

Affiliations

¹ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China.
² National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan 430070, China.
³ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China; National Laboratory for Veterinary Drug Safety Evaluation, Huazhong Agriculture University, Wuhan 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan 430070, China. Electronic address: chengguyue@mail.hzau.edu.cn.
⁴ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China; National Laboratory for Veterinary Drug Safety Evaluation, Huazhong Agriculture University, Wuhan 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan 430070, China. Electronic address: huanglingli@mail.hzau.edu.cn.

PMID: 34273851
DOI: 10.1016/j.ecoenv.2021.112503

Abstract

Cephalosporins are one of the most widely used antibiotics. When cephalosporins are discharged into the environment, they not only induce the production of antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARBs) but also cause toxic effects on animals and plants. Due to their complicated environmental behavior and lack of relevant data, the environmental behavior remains unclear. In this study, the adsorption-desorption and degradation characteristics of the third-generation cephalosporin drug ceftiofur (CEF) were investigated in three agricultural soils (sandy loam, loam and clay). According to the relevant parameters of the Freundlich adsorption isotherm (the K_f range was 57.63-122.44 μg^1-1/n L^1/n kg^-1), CEF was adsorbed moderately in the soils and had the potential to migrate into groundwater. CEF exhibited low persistence in the soils and faster degradation than other antibiotics, such as tetracyclines and fluoroquinolones. The degradation half-lives (DT50) of CEF in soils ranged from 0.76 days to 4.31 days. Adding feces, increasing the water content, providing light and increasing the temperature significantly accelerated the degradation of CEF in soils. The DT50 values of CEF in soils were significantly prolonged when the soils were sterilized, indicating that both physical degradation and biodegradation played important roles in the degradation of CEF in soils. The DT50 values of CEF in soils were significantly prolonged at high concentrations, indicating that the degradability of CEF in soils was affected by the initial concentration. No significant differences were observed in the DT50 values for the different soil types (p > 0.05). This study provides useful information about the environmental behavior of CEF and improves the environmental risk assessment of CEF.

Keywords: Adsorption-desorption; Ceftiofur; Degradation; Soil.

MeSH terms

Adsorption
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Animals
Cephalosporins
Kinetics
Soil Pollutants* / analysis
Soil*

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Cephalosporins
Soil
Soil Pollutants
ceftiofur