Vibrational spectroscopy for decoding cancer microbiota interactions: Current evidence and future perspective

Zhenhui Liu; Sheetal Parida; Ram Prasad; Rishikesh Pandey; Dipali Sharma; Ishan Barman

doi:10.1016/j.semcancer.2021.07.004

Vibrational spectroscopy for decoding cancer microbiota interactions: Current evidence and future perspective

Semin Cancer Biol. 2022 Nov;86(Pt 3):743-752. doi: 10.1016/j.semcancer.2021.07.004. Epub 2021 Jul 14.

Authors

Zhenhui Liu¹, Sheetal Parida², Ram Prasad³, Rishikesh Pandey⁴, Dipali Sharma⁵, Ishan Barman⁶

Affiliations

¹ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
² Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
³ Department of Botany, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar, 845401, India.
⁴ Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
⁵ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. Electronic address: dsharma7@jhmi.edu.
⁶ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: ibarman@jhu.edu.

PMID: 34273519
DOI: 10.1016/j.semcancer.2021.07.004

Abstract

The role of human microbiota in cancer initiation and progression is recognized in recent years. In order to investigate the interactions between cancer cells and microbes, a systematic analysis using various emerging techniques is required. Owing to the label-free, non-invasive and molecular fingerprinting characteristics, vibrational spectroscopy is uniquely suited to decode and understand the relationship and interactions between cancer and the microbiota at the molecular level. In this review, we first provide a quick overview of the fundamentals of vibrational spectroscopic techniques, namely Raman and infrared spectroscopy. Next, we discuss the emerging evidence underscoring utilities of these spectroscopic techniques to study cancer or microbes separately, and share our perspective on how vibrational spectroscopy can be employed at the intersection of the two fields. Finally, we envision the potential opportunities in exploiting vibrational spectroscopy not only in basic cancer-microbiome research but also in its clinical translation, and discuss the challenges in the bench to bedside translation.

Keywords: Cancer; Human microbiota; Raman spectroscopy; Ramanome; Vibrational spectroscopy.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microbiota*
Neoplasms*
Spectrum Analysis, Raman / methods
Vibration

Abstract

Publication types

MeSH terms

Grants and funding