Semiconductor small molecule IHIC/ITIC applied to photothermal therapy and photoacoustic imaging of tumors

Tingting Han; Yang Chen; Yifan Wang; Song Wang; Hailin Cong; Bing Yu; Youqing Shen

doi:10.1016/j.jphotobiol.2021.112257

Semiconductor small molecule IHIC/ITIC applied to photothermal therapy and photoacoustic imaging of tumors

J Photochem Photobiol B. 2021 Aug:221:112257. doi: 10.1016/j.jphotobiol.2021.112257. Epub 2021 Jul 10.

Authors

Tingting Han¹, Yang Chen¹, Yifan Wang¹, Song Wang¹, Hailin Cong², Bing Yu³, Youqing Shen⁴

Affiliations

¹ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China.
² Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China.
³ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China. Electronic address: yubing198@qdu.edu.cn.
⁴ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China; Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

PMID: 34271410
DOI: 10.1016/j.jphotobiol.2021.112257

Abstract

Organic semiconductor small molecules IHIC and ITIC have been developed as solar cell materials, and because of their strong near-infrared absorption capabilities, they are promising for cancer phototherapy. This article reports the application of semiconductor small molecule IHIC/ITIC liposomes in photothermal therapy and photoacoustic imaging of tumors firstly. Experiments show that the liposome-loaded IHIC/ITIC material has good biocompatibility and can be effectively enriched in tumor sites. After being irradiated with laser, it can emit strong photoacoustic signals, and has achieved good results in the photothermal treatment of breast cancer mice. We believe that organic semiconductor small molecule IHIC/ITIC will become a promising photothermal agent with wonderful development possibilities.

Keywords: IHIC; ITIC; Liposome; Organic semiconductor small molecule; Photoacoustic imaging; Photothermal therapy.

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / metabolism
Biocompatible Materials / pharmacology
Biocompatible Materials / therapeutic use
Cell Survival / drug effects
Endocytosis / drug effects
Endocytosis / radiation effects
HeLa Cells
Humans
Lasers
Liposomes / chemistry
Mice
Mice, Nude
Microscopy, Confocal
Neoplasms / diagnostic imaging
Neoplasms / drug therapy*
Neoplasms / pathology
Particle Size
Photoacoustic Techniques
Photosensitizing Agents / chemistry
Photosensitizing Agents / metabolism
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use*
Photothermal Therapy
Semiconductors*
Transplantation, Heterologous

Substances

Biocompatible Materials
Liposomes
Photosensitizing Agents