Decoding the complexity of circular RNAs in cardiovascular disease

Amit Kumar Rai; Brooke Lee; Carleigh Hebbard; Shizuka Uchida; Venkata Naga Srikanth Garikipati

doi:10.1016/j.phrs.2021.105766

Decoding the complexity of circular RNAs in cardiovascular disease

Pharmacol Res. 2021 Sep:171:105766. doi: 10.1016/j.phrs.2021.105766. Epub 2021 Jul 13.

Authors

Amit Kumar Rai¹, Brooke Lee¹, Carleigh Hebbard¹, Shizuka Uchida², Venkata Naga Srikanth Garikipati³

Affiliations

¹ Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
² Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, Denmark.
³ Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: venkata.garikipati@osumc.edu.

PMID: 34271160
DOI: 10.1016/j.phrs.2021.105766

Abstract

Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.

Keywords: Cardiovascular Disease; Circular RNA; RNA binding proteins and micro RNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / genetics*
Humans
RNA, Circular* / metabolism

Substances

RNA, Circular