The Role of FTO in Tumors and Its Research Progress

Abstract

Background: Malignant tumor is a disease that seriously threatens human health. At present, more and more research results show that the pathogenesis of different tumors is very complicated, and the methods of clinical treatment are also diverse. This review analyzes and summarizes the role of fat mass and obesity associated (FTO) gene in different tumors, and provides a reference value for research and drug treatment methods.

Methods: We conducted a comprehensive literature search using the database. According to the main purpose of the article, irrelevant articles were excluded from the research summary and included in the relevant articles. Finally, the relevant information of the article was summarized.

Result: In this article, the relationship between malignant tumors and FTO is introduced by citing many documents. In addition, the inhibitors that act on FTO are listed.

Conclusion: This article has shown thatFTO protein is a demethylase that can regulate N6-methyladenosine (m⁶A) levels in mRNA and plays a key role in the progression and resistance of various tumors such as leukemia, breast cancer, and lung cancer.

Keywords: FTO; gene; inhibitor; m6A; protein; tumor.