Antiproliferative activities of auraptenol against drug-resistant human prostate carcinoma cells are mediated via programmed cell death, endogenous ROS production, and targeting the JNK/p38 MAPK signal pathways

J BUON. 2021 May-Jun;26(3):1183.

Abstract

The Editors of JBUON issue an Expression of Concern to 'Antiproliferative activities of auraptenol against drugresistant human prostate carcinoma cells are mediated via programmed cell death, endogenous ROS production, and targeting the JNK/p38 MAPK signal pathways', by Yunli Liu, Xuedong Li, Zhaoyan Chen, Yunhui Chan; JBUON 2020;25(1):454-459; PMID: 32277668. Following the publication of the above article, readers drew to our attention that part of the data was possibly unreliable. We sent emails to the authors with a request to provide the raw data to prove the originality, but received no reply. Therefore, as we continue to work through the issues raised, we advise readers to interpret the information presented in the article with due caution. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.

Publication types

  • Expression of Concern

MeSH terms

  • Apoptosis
  • Carcinoma*
  • Coumarins
  • Humans
  • Male
  • Pharmaceutical Preparations*
  • Prostate / metabolism
  • Reactive Oxygen Species
  • Signal Transduction
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Coumarins
  • Pharmaceutical Preparations
  • Reactive Oxygen Species
  • auraptenol
  • p38 Mitogen-Activated Protein Kinases