The first reported case of Noonan syndrome complicated with hepatocellular carcinoma

Satoru Kakizaki; Daisuke Uehara; Hiroki Tojima; Takayoshi Suga; Yuichi Yamazaki; Ken Sato; Norio Kubo; Ken Shirabe; Takayuki Yokota; Kei Shibuya; Tatsurou Maehara; Hideaki Yokoo; Atsushi Naganuma; Toshio Uraoka

doi:10.1002/ccr3.4317

The first reported case of Noonan syndrome complicated with hepatocellular carcinoma

Clin Case Rep. 2021 Jul 9;9(7):e04317. doi: 10.1002/ccr3.4317. eCollection 2021 Jul.

Authors

Affiliations

¹ Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Maebashi Japan.
² Department of Clinical Research National Hospital Organization Takasaki General Medical Center Takasaki Japan.
³ Department of General Surgical Science Gunma University Graduate School of Medicine Maebashi Japan.
⁴ Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Maebashi Japan.
⁵ Gunma University Heavy Ion Medical Center Maebashi Japan.
⁶ Department of Human Pathology Gunma University Graduate School of Medicine Maebashi Japan.
⁷ Department of Gastroenterology National Hospital Organization Takasaki General Medical Center Takasaki Japan.

Abstract

Noonan syndrome is a genetic multisystem disorder and is associated with mutation of genes encoding the proteins in the RAS-MAPK pathway. We reported the first case of Noonan syndrome complicated with hepatocellular carcinoma.

Keywords: Noonan syndrome; PTPN11; hepatocellular carcinoma.

Publication types

Case Reports