Interaction of ethanol with blood proteins

Ostrovsky YuM; I I Stepuro; A N Artsukevich; I B Zavodnik; N V Konovalova; E A Lapshina

Interaction of ethanol with blood proteins

Alcohol Alcohol Suppl. 1987:1:283-7.

Authors

Ostrovsky YuM¹, I I Stepuro, A N Artsukevich, I B Zavodnik, N V Konovalova, E A Lapshina

Affiliation

¹ Institute of Biochemistry, Byelorussian SSR Academy of Sciences, Grodno, USSR.

PMID: 3426692

Abstract

At concentrations arising in alcohol intoxication ethanol was reversibly bound to human serum albumin and hemoglobin. Alcohol altered the conformation and stability of the proteins, reduced the domain-domain interactions in the molecule of albumin and changed the binding of such hydrophobic ligands as ANS and bilirubin.

MeSH terms

Bilirubin / metabolism
Blood Proteins / metabolism*
Ethanol / pharmacokinetics*
Ethanol / pharmacology
Hemoglobins / metabolism
Humans
Methemoglobin / metabolism
Oxyhemoglobins / metabolism
Protein Conformation / drug effects
Serum Albumin / metabolism

Substances

Blood Proteins
Hemoglobins
Oxyhemoglobins
Serum Albumin
Ethanol
Methemoglobin
Bilirubin