Toxicological assessment method for evaluating the occupational risk of dynamic olfactometry assessors

Regul Toxicol Pharmacol. 2021 Oct:125:105003. doi: 10.1016/j.yrtph.2021.105003. Epub 2021 Jul 12.

Abstract

The paper aims to propose a new method to evaluate the occupational exposure risk for examiners involved in dynamic olfactometry. Indeed, examiners are possibly exposed to hazardous pollutants potentially present in odorous samples. A standardized method to evaluate the examiners' occupational safety is not yet available and the existing models present some critical aspect if applied to real odorous samples (no uniform reference concentrations applied and presence of compounds for which no toxicity threshold is available). A deepening of assessment procedure to evaluate the occupation exposure risk for olfactometric assessors is necessary. This paper proposes a standardized approach for risk assessment in dynamic olfactometry. The proposed approach allows the quantification synthetic and conservative risk indices. In this model, the use of the hazard index for the odorous mixture was proposed to assess the non-carcinogenic risk; the calculation of the inhalation risk was applied to estimate the carcinogenic risk. Different databases can be used to retrieve proper occupational exposure limits, according to the proposed hierarchical basis. These implementations allow obtaining the complete characterization of real samples which can be used to calculate the minimum dilution factor for protecting the panellists' health.

Keywords: Occupational health; Occupational risk assessment; Odorous emissions; Olfactometric analysis; Olfactometric examiners.

MeSH terms

  • Environmental Monitoring / methods*
  • Environmental Monitoring / standards
  • Humans
  • Occupational Exposure / analysis*
  • Occupational Exposure / standards
  • Odorants / analysis*
  • Olfactometry / methods*
  • Olfactometry / standards
  • Risk Assessment