MICAL2 fine-tunes Arp2/3 for actin branching

Michael F Olson; Laura M Machesky

doi:10.1083/jcb.202106176

MICAL2 fine-tunes Arp2/3 for actin branching

J Cell Biol. 2021 Aug 2;220(8):e202106176. doi: 10.1083/jcb.202106176. Epub 2021 Jul 15.

Authors

Michael F Olson¹, Laura M Machesky²

Affiliations

¹ Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.
² Cancer Research UK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

Abstract

The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Actin Cytoskeleton
Actin-Related Protein 2-3 Complex* / genetics
Actins*

Substances

Actin-Related Protein 2-3 Complex
Actins

Abstract

Publication types

MeSH terms

Substances

Grants and funding