Chronic wireless neural population recordings with common marmosets

Jeffrey D Walker; Friederice Pirschel; Marina Sundiang; Marek Niekrasz; Jason N MacLean; Nicholas G Hatsopoulos

doi:10.1016/j.celrep.2021.109379

Chronic wireless neural population recordings with common marmosets

Cell Rep. 2021 Jul 13;36(2):109379. doi: 10.1016/j.celrep.2021.109379.

Authors

Jeffrey D Walker¹, Friederice Pirschel², Marina Sundiang³, Marek Niekrasz⁴, Jason N MacLean⁵, Nicholas G Hatsopoulos⁶

Affiliations

¹ Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA. Electronic address: walkerjd@uchicago.edu.
² Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA.
³ Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA.
⁴ Department of Surgery, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA.
⁵ Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Neurobiology, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA.
⁶ Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA.

Abstract

Marmosets are an increasingly important model system for neuroscience in part due to genetic tractability and enhanced cortical accessibility, due to a lissencephalic neocortex. However, many of the techniques generally employed to record neural activity in primates inhibit the expression of natural behaviors in marmosets precluding neurophysiological insights. To address this challenge, we have developed methods for recording neural population activity in unrestrained marmosets across multiple ethological behaviors, multiple brain states, and over multiple years. Notably, our flexible methodological design allows for replacing electrode arrays and removal of implants providing alternative experimental endpoints. We validate the method by recording sensorimotor cortical population activity in freely moving marmosets across their natural behavioral repertoire and during sleep.

Keywords: marmoset; motor control; multi-electrode arrays; natural behavior; wireless neural recording.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Behavior, Animal
Biomechanical Phenomena
Callithrix
Electrodes, Implanted
Feeding Behavior
Female
Male
Movement / physiology
Neurons / physiology*
Sleep / physiology
Titanium
Wireless Technology*

Substances

Titanium

Abstract

Publication types

MeSH terms

Substances

Grants and funding