Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome

Abstract

Purpose: To evaluate whether the systemic oxidative stress biomarkers increased in patients with vitreomacular traction syndrome (VMT).

Methods: This study compared 25 patients diagnosed with VMT with 20 healthy controls. As a biomarker of systemic oxidative stress, malondialdehyde (MDA) was measured. Total oxidant status (TOS) and total antioxidant status (TAS) were measured to evaluate the systemic oxidant status.

Results: Serum MDA values were significantly higher among the patients (p < 0.001). The ideal cut-off value for MDA was determined to be 22.1 µmol/L, with 80% sensitivity and 75% specificity. The between-group differences were not statistically significant for TOS or TAS (p = 0.326 and p = 0.698, respectively).

Conclusion: Increased MDA levels suggest that systemic oxidative stress may play a role in VMT.

Keywords: Malondialdehyde; Oxidative stress; Total antioxidant status; Total oxidant status; Vitreomacular traction syndrome.